Omega-3 fatty acids may prevent progression of AMD, according to studyp

Jun 22, 2009
Ophthalmology Times

Medford, MA—Omega-3 fatty acids found in fish such as tuna and salmon may protect against progression of age-related macular degeneration (AMD). The benefits, however, seem to depend on the stage of the disease and whether certain supplements are taken, report researchers at the Laboratory for Nutrition and Vision Research (LNVR), Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University.

Researchers calculated intakes of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from dietary questionnaires administered to 2,924 men and women, aged 55 to 80 years, participating in the Age-Related Eye Disease Study (AREDS) of the National Eye Institute (NEI).

The AREDS trial results suggest taking supplements of antioxidants plus zinc prevents progression of late-stage AMD. AREDS study participants were randomly assigned to receive either a placebo or supplements containing the antioxidants vitamins C and E and beta carotene, the minerals zinc and copper, or a combination of both.

“In our study, we observed participants with early stages of AMD in the placebo group benefited from higher intake of DHA, but it appears that the high-dose supplements of the antioxidants and/or the minerals somehow interfered with the benefits of DHA against early AMD progression,” said senior author Allen Taylor, PhD, director of the LNVR at the USDA HNRCA. Taylor also is a professor at the Friedman School of Nutrition Science and Policy at Tufts and Tufts University School of Medicine (TUSM).

The antioxidant supplements did not seem to interfere with the protective effects of DHA and EPA against progression to advanced stages of AMD. Participants who consumed higher amounts of DHA and EPA appeared to have lower risk of progression to both wet and dry forms of advanced AMD.

“Data from the present study also shows the supplements and omega-3 fatty acids collaborate with low-dietary glycemic index (dGI) diets against progression to advanced AMD,” said corresponding author Chung-Jung Chiu, DDS, PhD, a scientist in the LNVR and an assistant professor at TUSM. “Our previous research suggests a low-GI diet may prevent AMD from progressing to the advanced stage. We hypothesize that the rapid rise of blood glucose initiated by high-GI foods results in cellular damage that retinal cells cannot handle, thus damaging eye tissues.”

“Taken together, these data indicate that consuming a diet with higher levels of omega-3 fatty acids, antioxidants and low-GI foods may delay compromised vision due to AMD,” Dr. Taylor said. “The present study adds the possibility that the timing of a dietary intervention as well as the combination of nutrients recommended may be important.”

Column stresses importance of rubbing as well as rinsing contact lenses.

In the Health Answers column in the Boston Globe (6/30), Judy Foreman answers a question from a reader who asked, “Do you have to rub contact lenses to clean them if your cleanser is ‘no rub?’” Foreman explains that, “according to a new consumer ‘reminder’ from the” FDA, the agency “is now advising lens wearers to rub as well as rinse lenses, a policy supported by the…American Optometric Association.” The FDA’s “recommendations apply even if” a “product is advertised as ‘no rub,’ and also include throwing out cleansers by the discard date, washing…hands when handling lenses,” and letting the “lens storage case to dry (upside down, so water can drain) when lenses are removed.” Just “this month, the FDA wrote to the nine companies allowed to market ‘no rub’ lenses,” asking them to “‘come in’ to discuss the new data on lens cleaning,” according to “Dr. Dan Schultz, director of the FDA Center for Devices and Radiological Health.”

Segment explains computer vision syndrome.

On its website and on the air, KPIX-TV San Francisco, a CBS affiliate, reported that with “more than four billion mobile devices, and a countless number of computers…now in use around the world,” many with small display screens, a “high-tech eye problem is staring right back.” According to a survey by the California Optometric Association, “10 million patient visits” may result annually “from problems occurring with the use of high-tech devices.” In fact, optometrist Dennis Fong, OD, of the University of California-Berkeley’s School of Optometry, “has seen an uptick in a condition called computer vision syndrome, or CVS for short, the symptoms” of which include “headaches, tired eyes, blurred vision, double vision, and/or loss of eye focus.” Dr. Fong pointed out that “human eyes are not designed to look up close at anything for eight hours a day. In addition, high tech devices emit light…that causes eye strain.” He recommended that patients “invest in a pair of computer glasses” which allow people to “have an even larger area through which to see a display screen clearly.”

Use of inhaled corticosteroids may increase risk for cataracts in dose-dependent manner, research suggests.

MedWire (8/7, Cowen) reports that, according to a meta-analysis published online Aug. 2 in the journal Respirology, “the use of inhaled corticosteroids (ICS) may increase the risk for cataracts in a dose-dependent manner.” For their analysis, researchers from the Medical Research Institute of New Zealand “searched MEDLINE for the years 1950-2007 and EMBASE for the years 1988-2007 for all case-control studies of cataracts and ICS use.” Data from “four studies involving 46,638 cases and 146,378 controls” were used. Their “analysis…revealed a significant association between ICS dose and the risk for cataracts.” In fact, “the risk for cataracts increased by 25 percent with each 1000 µg per day increase in the dose of beclomethasone dipropionate, or equivalent.” The authors concluded, “These findings reinforce the importance of prescribing the lowest effective dose of ICS therapy in both asthma and COPD,” adding that “screening for the presence of cataracts could usefully be undertaken in older subjects with asthma and COPD.”

Article details how eye exams can detect serious diseases elsewhere in body

The UK’s Daily Mail (8/4, Lambert) reports that “research from the” UK’s “College of Optometrists suggests that a quarter of adults have gone for more than two years without having their eyes examined, while 18 percent have left it more than three years.” Putting off an eye examination may be risky, since “optometrists are trained not just to pick up vision defects, but also to spot symptoms in the eye that are a sign of a dozen serious diseases elsewhere” in the body. The article goes on to detail the experience of five patients ranging in age from 23 to 72 whose optometrists discovered ulcerative colitis, pilocytic astrocytoma, myasthenia gravis, type 1 diabetes, and dangerously high blood pressure during routine eye examinations

Survey suggests nearly two-thirds of children under six have never had an eye examination

HealthDay (8/3, Preidt) reported that, according to a survey conducted by Prevent Blindness America and VSP Vision Care, “more than 20 percent of kids aged 12 to 17 have trouble seeing the classroom chalkboard.” Specifically, “of the nearly 1,500 children in the survey, more than 25 percent of the teen age group complained of headaches, even though 45 percent of them wore some type of prescription eyewear.” Approximately “25 percent of children aged six to 11 wear prescription glasses.” Children’s eye problems also increased with age, with myopia being “the most common vision problem in older children.” Notably, the survey indicated that “more than 66 percent of those under the age of six have never had their eyes examined by an eye doctor.” Prevent Blindness America urged parents to have their children’s “vision checked regularly.”

Researchers developing new understanding of glaucoma.

In the New York Times (7/15) Times Essentials: Reporter’s File, Peter Jaret observed that “a new paradigm for understanding glaucoma has emerged. Glaucoma isn’t simply an eye disease, experts now say, but rather a degenerative nerve disorder, not unlike Alzheimer’s or Parkinson’s disease.” While “researchers still recognize high pressure within the eye as a leading risk factor for glaucoma,” it is becoming clear that the condition “begins with injury to the optic nerve as it exits the back of the eye. The damage then spreads, moving from one nerve cell to adjoining nerve cells.” Neeru Gupta, MD, PhD, of the University of Toronto, explained, “In glaucoma, we’ve shown that when your retinal ganglion cells are sick, the long axons that project from the eye into the brain are also affected, resulting in changes that we can detect in the vision center of the brain.” This “phenomenon, called transynaptic damage, occurs in Alzheimer’s and Parkinson’s disease, as well.”

Glaucoma surgeries increasing while Medicare reimbursement decreases, study suggests. MedPage Today (7/15, Fiore) reported that, according to a study published in the July issue of the Archives of Ophthalmology, “the number of glaucoma surgeries is on the rise, but Medicare reimbursement for the procedures has been decreasing.” For the study, researchers from Exponent, Alcon Research, and the Bloomberg School of Public Health analyzed “Part B Medicare data for 100,000 beneficiaries from 1997 to 2006.” The team “found that from 1997 to 2001, there was an overall decrease in both the number of procedures and the amount of annual payments, but there was an increase in the number of procedures in the following years, reaching a total of 414,980 in 2006.” The investigators attributed the increase to “advancements in technology and a change in calculating the global period for reimbursement purposes.” The authors also “noted that payments for trabeculectomies decreased over time, while annual payments for newer procedures, such as cyclophotocoagulation and shunt-related procedures, have increased.”

Optometrist advises parents to protect children’s eyes against UV rays.

Utah’s Standard-Examiner (7/17, Park) reported that “July is ‘UV Awareness Month,’ and besides protecting children from sunburns, adults also need to protect the eyes of children from the sun’s ultraviolet rays.” Optometrist Renny Knowlton, OD, advised parents to exercise “good judgment and common sense.” Children who “spend a good deal of time in the sun” need to “protect their eyes with sunglasses coded for UVA and UVB rays, he said. Some children will not wear sunglasses for long, so have them wear a hat with a brim to help shade their eyes.” According to Whitney Johnson, health educator with the Utah Cancer Control Program with the state health department, “parents should buy sunglasses with a UV rating,” and should consult with “an eye doctor” to find out which sunglasses are best. And, “to protect children’s eyes while playing in the water or swimming outside, Johnson said, children should wear sun goggles that also have UV protection ratings.”

How Diet Can Be Used as a Tool to Reduce Risk of Macular Degeneration

The macula is the area of the eye responsible for our sharp, central vision.  Everything we look directly at, be it a face or print on a written page is identified by the macula of the eye.  The macula consists of densely packed cells called photoreceptors. When light hits these photoreceptors, the signal is transmitted through to nerves that lead to the vision center of the brain.  In macular degeneration or other disease of the macula, the photoreceptors are damaged and unable to transmit the image to the brain. Healthy photoreceptors mean a healthy macula.

The macula serves your keenest central vision, so damage to this area is responsible for loss of detail, like face recognition or difficulty discerning print on a page.

Damage to the macula occurs when molecules in and around the area of the macula are “oxidized”, or broken down.   UV light is one of the culprits – the eye focuses much of the incoming light onto the macula and a such, the macula is exposed to more UV than other parts of the internal eye.  UV light is an “oxidant” and can cause breakdown of integral components in and near the macula.  Another major cause of oxidation in the macula is the blood stream, which contacts the macula from below.  Smokers and people with poor diets are exposed to more oxidants through the blood stream than non-smokers and people with healthy diets, leading to greater risk of macular degeneration.  There is also a strong genetic component in some people, so they may smoke and have a poor diet and never develop macular degeneration while their spouse may have the same habits and develop it.

Diets high in antioxidants have been shown to reduce risk of developing macular degeneration (AREDS study).

Specific antioxidants that help reduce risk of Macular degeneration include Lutein, Zeaxanthin and meso-Zeaxanthin.  Intake of Omega 3 fatty acids has also been suggested to benefit the macula, specifically Olive oil.  While vitamins are available to supplement the intake of these micronutrients, the body best absorbs them by eating fresh fruits and vegetables, specifically fresh spinach.   Spinach is the new “carrots” for the eye – extremely beneficial in people with family histories of macular degeneration.  Be careful when taking fish oil supplements if you are male, as some supplements and the vehicles in which they are ingested have been tied to prostate problems.  The National Eye Institute sponsored a the Age Related Eye Disease Study (AREDS) which determined the benefit of specific nutrients that may help to reduce the risk of progression of macular degeneration.

I try to eat a fresh spinach salad with a teaspoon of olive oil on it everyday to reduce my risk as we have a family history of macular degeneration and I recommend my patients do the same

Anatomical position of the macula of the eye

Anatomical position of the macula of the eye

Courtesy of the Doctors at Shady Grove Eye and Vision Care; Optometrists, Ophthalmologists and Opticians serving Rockville, Gaithersburg and Potomac Maryland suburbs of Washington DC for over 40 years.

Follow Dr. Glaziers tweets @Eye Info

For more information on eye and vision care issues visit youreyesite.com

 

 

Why Close Work Can Cause Vision Change

Difficulty attempting to view distance objects is cause for most visits to the eye doctor. Road signs may seem a little blurry at first, then it becomes difficult to see the TV set or the jersey numbers on the basketball players at the arena. Examination by an eyecare professional usually results in a prescription change that corrects the blur. The blur may return over time. The person watches their prescription numbers increase year after year as lens thickness increases, dreading the day the doctor prescribes “coke-bottle” thick eyeglasses. The patient feels helpless in the wake of these increases. Many doctors discuss the vision change to the patient, insinuating prescription increases are normal and to be expected over time. The problem with this scenario is the development of the visual system (including the eye) is complete by adulthood. Then why is the vision changing? Genetic influences are the most likely cause of vision changes before adulthood and can be expected. Changes in distance vision should not continue to progress on a regular basis (excluding astigmatism) after the development of the visual system is completed through natural growth. The progression of Myopia (nearsightedness) during development of the visual system can be compounded by a dysfunction in the focusing mechanism (lens) of the eye, making the changes greater than they would have been through genetics alone. Any changes in vision after the complete development of the visual system is likely to have been brought about by problems causing over-focus (locking in of focus when viewing near objects) when looking at distance objects. Over-focus and failure to release focus to look at distance is a cause of progressive vision changes in adults. There are many ways to manage progression of distance blur.

THE NEAR TRIAD

The eye receives light and processes it as described in the section Anatomy of the Eye. This process is similar for viewing near and distant objects. Looking at distance objects differs from looking at near objects in how the musculature of the eye adjusts the focus mechanism, the Lens. Adjustment of focus for viewing near objects is termed Accomodation. When viewing distance objects (objects greater than 20 feet or 6 meters from our eyes), the eyes are aligned straight ahead and the line of sight of each eye is approximately parallel to one another. Light from the distance target enters the eye and is focused on the Retina, or light -sensitive tissue on the back of the eye. When looking from a distance target to a near target, the eyes must change focus. The eyes must also turn in towards each other to bring proper focus onto the near object (Convergence). This change in focus only occurs when looking from Distance to near. When looking up from near work, or near to distance, the eye un-focuses (releases accomodation) and the eyes straighten and the lines of sight go from being converged on a near target to being parallel again. The process of going from a position of convergence (looking at near) and accomodation (focusing at near) to being straight and unaccomodated for distance viewing is called divergence. The processes of convergence and divergence are controlled by the musculature surrounding the eye. These muscle actions for convergence and divergence are intertwined with the muscle that controls the focus for the lens of the eye so when the eye converges, the eye muscle focuses the lens for near and when the eye diverges, the eye muscle unfocuses the lens for distance. The eye muscles receive information for when to converge or diverge, direct the eyes to the left, the right, up or down based on information shared between the retina (image positioning information) and the nuclei (eye movement information). If an object passes to the left of you, the image of the object will fall on an area of the retina that corresponds to your left side. The nuclei will receive this signal and relay another signal to the eye muscles to look left in order to move the image of the object towards the area of the retina where the image is best viewed (the Fovea). Muscles inside the eye then control the process of accomodation and unaccomodation. When the act of focusing occurs, the mind assumes that a near object is to be viewed and convergence action kicks in. How does the mind know you are viewing a near target? When an object directly in front of you is brought closer to you, the image size of the object projected on the retina increases and the retinal image blurs. This slight amount of blur is the stimulus for the focus mechanism to kick in. Proximity of the object and blur are stimuli that activate the convergence/accomodation nuclei in the brain. The visual system transfers information about object proximity and blur to nuclei responsible for accomodation. Impulses are sent through the accomodation/convergence pathway. The impulses cause muscles inside the eye to increase the convexity of the lens of the eye. The increase in convexity increases focusing power, enabling focus at near. These stimuli cause accomodation for near and the eyes converge. When the object moves away from you, the image magnification on the retina decreases, the stimulus to converge and focus for near decreases as the eyes diverge to see the object at distance. The muscles in the eye cause the convexity of the lens to decrease, decreasing focusing power. This moves the point of focus out to distance. There is no convergence without accomodation and no accomodation without convergence. There is no divergence without unaccomodation and vice-versa.

A brief synopsis before continuing: To view objects at distance (greater than 20 feet or 6 meters), the visual system causes the focus mechanism to un-focus or relax. When looking at near, the vision system causes the lens of the eye to accommodate to focus on a near point. This accomodation is achieved by increasing the convexity of the lens of the eye. Accomodation is the process of moving the distance point of focus on the retina to the near point of focus by increasing or decreasing the convexity of the lens of the eye. To look at it in a different light (no pun intended) accomodation is the process of moving a distance point of focus to a near point of focus by increasing convexity of the lens. Spasm of accomodation, or pseudo-myopia occurs when the convexity achieved for the near point of focus “locks in” and won’t release again to view distance objects clearly. An example of “locking in” is seen in college students. Many patients in the late 20′s and early 30′s report having had perfect vision until sometime during or immediately after their college years. The first change they note in vision was blur at distance after reading, studying or hours of computer work. They report looking up from a book after a study session, then blinking a few times or squinting to see far away again. There far away vision gradually returned, but slower and slower until the distance vision was slightly blurry permanently. Then, going for an eye exam where the chief complaint they tell the doctor is distance blur, they are prescribed eyeglasses for distance, see better and become dependent on the glasses, but the whole time the near problem was never addressed. So, their vision blurs at distance, is tweeked in an eye exam and the problem continues. If the student had only told the doctor that the problem was the change in focus from distance to near, they may have been prescribed glasses to help them focus at near (reading or computer glasses). That may have solved the problem and halted a problem that gradually leads to a need for glasses at distance full time. Clearing someone’s distance vision is no-brainer for your eye-care professional. You could leave a patient alone in the examination room with the ‘better #1 or better #2 machine and within 5 minutes they could find a prescription that could clear the bottom line of the eye chart. The person determines whether 1 or 2 is better at distance, gets shown to the optical and another nearsighted person is created. The problem was not at distance, but at near. The blur is not the consequence of continued development of the visual system. It is the first sign of visual change secondary to false distance blur, or Pseudo-myopia. People concentrate on print or virtual pixel images 16 to 19 inches in front of their nose for hours on end. After focusing at near for extended periods of time, the focusing system may lock in on the near image. When the person looks up, the distance image appears blurry. The neurological signal to focus for near is not letting go and blur is caused by looking at the distance object through the near focus. The person is looking far away, but their eye hasn’t let go the focus from the book or computer screen! The person is unable to relax accomodation for near back to distance. When they go for an eye exam, often distance glasses are prescribed. Distance glasses clear blur, but the problem of near over-focus remains and the cycle of annual prescription changes and increases continues. If the near point vision problem is not addressed, the progression of pseudo-myopia will eventually lead to more dependence on the distance prescription. Real doctoring involves identifying the cause of the changing vision and making recommendations to slow the vision changes down, stop them or reverse them.

The latest research on myopia is showing that depriving someone of peripheral vision might be another cause of increase in myopic prescriptions. When we look out at a distance, we use our central and peripheral vision. When we look close to read or do computer work, we use less of our peripheral vision. Lack of stimulation of the periphery over long periods of time can lead to prescription “creep” if one is genetically geared towards myopia. In order to minimize the effect one should increase their reading distance or computer working distance.

Human beings are highly adaptable organisms. The body will alter function to accommodate needs for which the system isn’t able to compensate for. After enough use, the adaptation, if successful, may become part of the system for which it was meant to modify. Incipient nearsightedness brought on by focus problems is an adaptation our technological society is adopting. Most people in school or in white-collar occupations spend 6 to 10 hours of their waking day involved in near activities. Pseudo myopia, or false near focus is the bodies’ modification for increased need to see at near. For many of my patients, clear distance vision is needed only for driving to and from work and going to the movies. If we continue to evolve in this manner, our descendents will find no need for glasses continuously perched on the bridge of their noses anymore. People will be buying cars with prescription windshields. Of course, this is an exaggeration. In this day and age, the need for clear, comfortable, functional vision at distance is not as great as that at near. The old paradigm for prescribing glasses may need to be tossed out the window if we, as doctors, are to truly manage patients vision problems. As an eye care provider I feel a responsibility to identify and solve problems, instead of offering crutches (eyeglasses/contact lenses) for patients to become more and more dependent on. I’m talking about solid management of the underlying vision problem, not the symptoms alone.

Courtesy of the Doctors at Shady Grove Eye and Vision Care; Optometrists, Ophthalmologists and Opticians serving Rockville, Gaithersburg and Potomac Maryland suburbs of Washington DC.  For more information visit youreyesite.com.  Follow us @EyeInfo

NOT a patient of Shady Grove Eye and Vision Care

NOT a patient of Shady Grove Eye and Vision Care

 

 

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